تلخیص
Background: The changing spectrum of micro-organisms causing urinary
tract infection (UTI) and emerging resistance to antimicrobials are
upcoming problems around the globe. Complicated UTI develops in
patients with immune deficiency and underlying renal defects
(anatomical or functional). The causative organisms in complicated UTI
are usually resistant and difficult to treat resulting in frequent
hospitalizations of patients. The aim of this study was to determine the
culture and sensitivity pattern of complicated UTI in pediatric population.
Material and Methods: A descriptive cross-sectional observational study
was performed utilizing prospective data in the Department of
Nephrology at The Children’s Hospital and The Institute of Child Health
Lahore Pakistan. A total of 49 patients with complicated UTI were
selected from July to December 2014.
Results: Amongst the 49 patients selected with complicated UTI, 69.4%
(n= 34) were males and 30.4% (n= 15) were females. The most common
causative organism was Klebsiella (40.0%) followed by E.Coli (26.0%) and
Peudomonas (16.0%). These organisms showed the highest sensitivity to
meropenem, piperacillin+tazobactam, amikacin and fosfomycin, while
resistance was observed for third-generation cephalosporins and
ciprofloxacin.
Conclusion: Klebsiella is the leading organism in complicated UTI and
there is high rate of resistance to commonly used antimicrobials.
Shahida Perveen , Faiz Ahmad Bhati, Iftikhar Ahmad Rabbani, Shadab Masood, Farkhanda Hafeez, Naureen Akhtar. (2016) Changing Trend of Uropathogens and Antimicrobial Sensitivity in Complicated Urinary Tract Infection in Children , Pakistan Pediatric Journal, Volume 40, Issue 1.
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