مقالے کی معلومات
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مقالے کی قسم
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تاریخِ موصولہ
تاریخِ قبولیت
تلخیص
Objectives: To screen close family members of Thalassemia children for
the presence of Thalassemia trait; To do genetics counseling of carriers
and at risk couples in families of thalassemic children for reducing the
burden of thalassemia in Multan region.
Study Design: A cross sectional Descriptive study.
Place And Duration Of Study:
Thalassemia centre, children hospital and Institute of child health Multan
from Jan 2013 to June 2014.
Material and Methods: Total ten Thalassemia patients’ families were
selected for the study. A meeting was held with parents of 10
Thalassemia children receiving blood transfusion at Thalassemia centre
CHC Multan. A total of 100 cases was screened for the presence of
Thalassemia. Screening was carried out in a step wise approach. Red
cell indices (Hb, MCV, MCH), serum ferritin and Hb –electrophoresis were
measured. First of all Red cell indices were measured by electronic
counter. When red cell indices showed microcytosis MCV <25 pg or MCV
75 fl, serum ferritin levels were measured to rule out iron deficiency
anemia. Cases that showed microcytosis with normal serum ferritin level,
Hb electrophoresis were sent. When Hb –electrophoresis showed HbA2
level 3.5% or more cases were labeled as Thalassemia. After completing
all lab work a counseling session was held with screened carriers and
their parents. Durning the counseling session, the results of screening
were given to carriers themselves or parents of children less than 15
years.
Results: In this study the total sample size was 100, out of which 59 (59%)
were females and 41(41%) were females. Mean age of sample was 15
years +/_ 5 years. Mean hemoglobin of sample was 12.3 +/_ 1.37.Out of
100 cases 37 (37%) were detected of having Thalassemia trait on Hb –
electrophoresis while 77(77%) had normal Hb –electrophoresis.
Saadia Khan, Imran Iqbal, Muhammad Aslam Sheikh, Kamran Ishfaq, Zaheer Ud Din Babar. (2016) Detection of Thalassemia Trait in Family Members of Children having Beta-Thalassemia and its Role in the Prevention of Thalassemia, Pakistan Pediatric Journal, Volume 40, Issue 2.
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