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Background: Glucose-6-phosphate dehydrogenase deficiency is an Xlinked recessive disorder, prevalent in 400 million individuals worldwide. It
constitutes a common inherited cause of neonatal jaundice.
Objectives: To determine the frequency of glucose-6-phosphate dehydrog
Place and Duration: Neonatal intensive care unit, National Institute of
Child Health, Karachi from 18th December 2013 to 17th June 2014.
STUDY DESIGN :Cross sectional study
Patients & Methods: All neonates with serum indirect bilirubin of >05 mg/dl
were hospitalized and included in the study. Bio data, detail history and
physical examination was performed. Blood sample for G6PD levels were
sent to the laboratory .G6PD level of < 6.97 IU/gHb was considered as
deficient & level ≥ 6.97 IU/gHb was considered as normal. Data was
analysed using SPSS version 20.P value of < 0.05 was considered
significant.
Results: A total of 131 neonates with jaundice were included in the study
Males were 78 (59.54%) and females were 53 (40.46%) with a ratio of
1.47:1. The age of patients ranged from 1 to 28 days with a mean age of
8.89 ± 5.34 days .Mean ± SD of bilirubin is 9.9 ± 3.2mg/dl. G6PD level was
deficient in 13 (9.92%) jaundiced neonates while 118 (90.08%) jaundiced
neonates had a normal level of G6PD enzyme. Among them 9 (69.23 %)
were male and 4 (30.77%) were female.
Conclusion: G6PD deficiency is a common inherited cause of neonatal
jaundice. It was seen in 9.9% of jaundiced neonates .
Mashal Khan, Kanwal Altaf Malik, Meheozia Nuzhat. (2016) G6PD Deficiency in Neonates with Jaundice , Pakistan Pediatric Journal, Volume 40, Issue 3.
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