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Objective: To assess the outcome of meconium aspiration syndrome (MAS) in neonates with meconium stained liquor admitted at neonatal intensive care unit of a tertiary care hospital. Study Design: Descriptive case series. Place and Duration of Study: Pediatric Department of Liaquat University, Hyderabad, 6 months from 1st November 2018 to 30th April 2019 Material and Methods: There were 186 neonates having history of meconium stained liquor or meconium staining of umbilical cord included in this study. Age, gender, weight, length, gestational age, mode of delivery, place of delivery, development of MAS and outcome were noted. Results: The average age of the neonates was 9.47 ± 8.41 hours. Frequency of meconium aspiration syndrome in neonates with the history of meconium stained liquor and/or meconium stained umbilicus was 70.97% (132 of 186) cases. Neonates were observed for 48 hours after birth for respiratory distress. In case of respiratory distress neonates were managed accordingly till improvement or death. Regarding meconium aspiration syndrome in neonates, respiratory distress at 0 hour was 86.4% (114 of 118) abnormal x-ray changes occurred in 67.4% (89 of 94) and death occurred in 34.8% (46 of 62). Conclusion: In this study significantly number of neonates aspirated meconium after passing meconium in the amniotic fluid. Respiratory distress soon after birth was also significant in neonates. A total of 67.4% (89 of 94) neonates had abnormal x-ray findings suggestive of meconium aspiration syndrome. Ratio of death was higher due to unavailability of ventilator support as well as surfactant.

JYOTI GOMANI, JYOTI GOMANI, MUHAMMAD NADEEM CHOCHAN, Muhammad Touseef, Mushtaque Ali Shah. (2021) Outcome of Meconium Aspiration Syndrome in Neonates at Tertiary Care Hospital, Pakistan Pediatric Journal, Volume 45, Issue 3.
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