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Objective: To study the outcome of valproic acid, carbamazepine, and levetiracetam single drug therapy on thyroid functions. Study Design: Analytical cross-sectional study. Place and Duration of Study: Study was done in Department of Pediatrics at King Fahad Armed Forces Hospital Southern Region, Saudi Arabia over three years period starting from March 2017 to February 2020. Material and Methods: A total of sixty patients, age range of the patients was from 2 years to 14 years, among them 34 (56.66%) were female and 26 (43.33%) were male with newly diagnosed epilepsy treated with valproate (n=24), carbamazipine (n=17), and levetiracetam (n=19) were registered in the study. Serum free thyroxine (f T4), triidothyronine (f T3) and thyroid stimulating hormone (TSH) were analysed before and six months after starting the treatment. Results: A baseline thyroid functions were normal in all sixty patients. Two patients in carbamazipine traeted group showed abnormal thyroid hormones results. Levetiracetam and valproate treated patients showed no remarkable change in f T3, f T4 and TSH serum levels. The density of subclinical hypothyroidism was only 3.33% overall and 11.76% in carbamazipine group. Conclusion: In conclusion, carbamazipine has inimical effects on where as levetiracetam and valproate did not affect thyroid function in epileptic patients during the period of 6-month treatment in our study.

MUHAMMAD SAEED, SAEED AL-FADHL, ALI QURESHI, Sanaa Gammaa, Abdul Qadir. (2021) Subclinical Hypothroidism in Children Treated with Antiepileptic Drugs, Pakistan Pediatric Journal, Volume 45, Issue 3.
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