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Objective: To study the clinical and laboratory profile and response to antibiotic therapy in typhoid fever. Study Design: Quasi experimental study Place and Duration of Study: The Children’s Hospital, Lahore from December 2019 to May 2020. Material and Methods: Total of 200 patients between 01 to 15 years of age who fulfilled the criteria of confirmed and clinically suspected cases. Data was analyzed by SPSS 20. Results: There were 120 males and 80 females. 52% of patients were under 5 years of age. Only 6% were using boiled water. Mean duration of fever was 14 ± 6 days. The most common symptom was anorexia (57%) and clinical sign was coated tongue (52%). Blood cultures were positive in 21%. All isolates were 100% sensitive to azithromycin and meropenem. None were sensitive to ciprofloxacin, ampicillin and chloramphenicol. 28% were sensitive to co-amoxiclav, 14% to Co-trimoxazole, 9.5% to ceftriaxone and cefixime each, 85% to amikacin and 81% to piperacillin-tazobactam. 37% patients responded to ceftriaxone, 35% to azithromycin and 25% to meropenem. Conclusion: Sensitivity pattern has revealed a significant proportion of multidrug and extensively drug resistant strains. Continued surveillance of resistance patterns and formulation of antibiotic therapy for a step wise approach accordingly as in our study for their judicious use is the need of hour.

AYSHA MANSOOR LODHI, ASMA MUSHTAQ, MUHAMMAD NASIR RANA, Wajiha Rizwan, Muhammad Sahir Saud. (2021) Clinical and Laboratory Profile and Response to Antibiotics in Typhoid Fever, Pakistan Pediatric Journal, Volume 45, Issue 2.
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