Objective: We aimed to identify whether Activin A levels are elevated in venous blood and/or urine samples of infants with hypoxic ischemic encephalopathy (HIE), and to determine if Activin A levels may be used as a diagnostic marker of hypoxic ischemic encephalopathy. Study Design: This was a case-control study. Place and Duration of Study: This study was performed at Cumhuriyet University Medical Faculty Newborn Clinic from July 2009 to December 2009. Material and Methods: We included 20 infants with hypoxic ischemic encephalopathy and 20 healthy newborns into this study and measured Activin A levels in venous blood and urine samples on the 1st, 2ndand 3rd days after birth. Results: Hypoxic ischemic encephalopathy and control groups were similar in terms of gender, pregnancy duration, weight, height, and head circumference. Blood and urine Activin A levels in 1st, 2nd, 3rd days were higher in those with hypoxic ischemic encephalopathy compared to healthy infants. Conclusion: As a result, Activin A level is an aid parameter that can be used in the diagnosis of HIE.
AYLIN BOZDOGAN, FEYZA USTABAS KAHRAMAN, BILGE BAYRAKTAR, Dilara Fusun Icagasioglu. (2021) Assessment of Blood and Urine Activin A Levels in Neonates with Hypoxic Ischemic Encephalopathy: A Case-Control Study, Pakistan Pediatric Journal, Volume 45, Issue 2.